ea0026p247 | Pituitary | ECE2011
Filopanti Marcello
, Olgiati Luca
, Lania Andrea
, Beck-Peccoz Paolo
, De Marinis Laura
, Grottoli Silvia
, Martini Chiara
, Cannavo Salvatore
, Bogazzi Fausto
, Ferone Diego
, Arnaldi Giorgio
, Peri Alessandro
, Tita Patrizia
, Pigliaru Francesca
, Angeletti Gabriella
, Jaffrain-Rea Marie-Lise
, Losa Marco
, Spada Anna
Introduction: To date, two pharmacogenetic studies investigated the effect of the common exon 3 deletion of GH receptor (d3-GHR) variant in small series of acromegalic patients treated with Pegvisomant (Peg), suggesting an association of d3-GHR allele with better response to Peg.Aim: To assess the influence of d3-GHR variant in a large cohort of acromegalics with active disease and resistance to somatostatin analogues (SSA) treated with either Peg monoth...